A new study has found that cannabidiol (CBD) attenuates aggression caused by social isolation, and many of our customers confirm that CBD flowers are effective in suppressing aggression, calming and relaxing. The study, based on a mouse model, was conducted by researchers at the University of São Paulo's Ribeirão Preto Medical School (FMRP-USP) in Brazil. The results were published in the journal Progress in Neuro-Psychopharmacology and Biological Psychiatry.
"Our study shows that cannabidiol can inhibit aggression, and it does so by facilitating the activation of two receptors: the 5-HT1A receptor responsible for the action of the neurotransmitter serotonin and the CB1 receptor responsible for the action of endocannabinoids," said Francisco Silveira Guimarães, full professor at FMRP-USP and leader of the study.
Dried CBD does not cause addiction or psychoactive effects. The component of marijuana responsible for these psychoactive effects is tetrahydrocannabinol (THC), and cannabidiol (CBD) reduces the effects of tetrahydrocannabinol.
"Cannabidiol has been studied in various contexts over the last 20 years, but very little research has been devoted to its effects on aggressive behavior," Guimarães said.
"Aggression caused by social isolation can be alleviated by administering anti-anxiety, antidepressant or antipsychotic drugs. Preclinical and clinical studies have shown that CBD has these properties, so we decided to test its effects on aggression," he said.
"We used a model known as the resident intruder test, which causes aggression in an animal kept in isolation for several days."
CBD vs Aggression
To determine whether the effects of cannabidiol could alter aggressive behavior, the researchers created four groups, each consisting of six to eight male mice, and then the mice were given different doses of CBD.
The fifth group acted as a control and did not receive cannabidiol. The mice in this group exhibited classic resident-intruder behavior. When non-resident cage mice were introduced to this group, they were attacked by residents after an average of two minutes. Between 20 and 25 attacks were recorded while the animals were in the same cage.
In the first group, the resident mice received a dose of 5 milligrams of CBD per kilogram (mg / kg), and each of the males weighed 30-40 grams. Attacks began about four minutes after the intruders entered the cage, twice as long as in the control group of mice, and the number of attacks dropped by half.
The second group received 15 mg of CBD per kilogram of body weight and behaved less aggressively than any other group. Attacks began an average of 11 minutes after the intruder arrived, and the number of attacks dropped to five.
The third and fourth groups received 30 mg CBD / kg and 60 mg CBD / kg, respectively, but these higher doses did not result in more intense inhibition of their aggression. The attacks started earlier, and the number of attacks was also slightly higher.